Netcare 911 responded to reports of a plane crash near the Airport in Joubert Street, Springs on Monday morning.
When medics arrived on scene, they found a single engine light aircraft with substantial damage on the center median.
The patients, both males had sustained minor to moderate injuries and were treated on scene before being transported by ambulance to hospital for further treatment.
Circumstances leading up to the incident with be investigated by the relevant authorities.
Details subject to change as more information becomes available.