Sundowns managed just a point in the last two Absa Premiership encounters and were taken to penalties by Chippa United in the TKO.
Mosimane says the results are part of a process adding that the league is a marathon.
Sundowns were held to a goalless draw by a 10-men Baroka FC in the league in Polokwane on Wednesday night missing out on a chance to close the gap between them and the side at the top of log Kaizer Chiefs.
The defending champions are without the trio of Phakamani Mahlambi, Themba Zwane and Gaston Sirino due to injuries. With the side still competing on three fronts, including the Caf Champions League, Mosimane says there is no need to panic.
Mosimane also backed the national Under23 side to do well at the Africa Cup of Nations tournament in Egypt starting on Friday.
David Notoane’s men must finish the tournament in the top three in order to qualify for next year’s Olympic Games in Tokyo, Japan.
Mosimane released Keletso Makgalwa this week to be part of the national squad and he adds that it is important to support national programmes.
South Africa open their account in Group B in Egypt against Zambia on Saturday before meeting Ivory Coast next Tuesday and lastly Nigeria next Friday. – Report by Lethabo Kganyago