The private meeting between Cardinal Philippe Barbarin and Pope Francis is expected to take place around 0900 GMT, according to his diocese, with the pontiff to decide within weeks whether to accept his resignation.
The Catholic Church in South Africa says bishops from around the world had a chance to do serious introspection about the sexual abuse of minors and subsequent cover ups.
Pope Francis kicks off a red-letter global child protection summit Thursday for reflections on the sex abuse crisis, while victims tired of hearing pledges for change clamour for incisive reforms.
After years of struggling alone or finding support in national groups, survivors of sex abuse by priests have formed a new international alliance to pressure the Catholic Church to face up to its crimes.
Pope Francis will gather bishops from around the world at the Vatican this week for a hotly-awaited summit on tackling the wave of child sex abuse scandals assailing the Catholic Church.