Their belief comes from their positive tour in Australasia where they lost just one out of three games.
There are a few changes to the starting line-up with Rob Du Preez Junior starting at flyhalf while Curwin Bosch moves to fullback.
Flank Dan Du Preez, who earned his 50th Super Rugby cap last weekend, discusses their approach to the game.
The margin for error against a team packed with international stars is very small. The South Americans seem to be peaking at just the right time, returning from their tour of Australasia with three out of four wins, beating the Canes, Reds and Waratahs.
Du Preez says they will have to take good care of the ball.
Du Preez says they do not have revenge on their minds after they conceded 50 points to the Jaguares in a harrowing defeat at home earlier in the season.
It was among the biggest defeat the Sharks have suffered in their history in the competition. Instead, Du Preez says they want to focus on what they can do to ensure they win the game. – Report by Thahir Asmal