They will battle against seven other African countries Botswana, Lesotho, Zimbabwe, Nigeria, Kenya, Tanzania and Uganda.
The matches will take place at Crafford stadium in Rietondale, Pretoria.
Softball SA President Mashilo Matsetela says the recently launched national league has prepared the players.
The top two teams in the qualifier will advance to the Europe/Africa qualifiers in Netherlands later this year.
The winner of Africa/Europe qualifiers will automatically qualify for the Olympics in Tokyo according to Matsetela. – Report by Vincent Sitsula