The Global Fund is a group of governments, civil society and private sector partners which invests around $4 billion a year to fight infectious diseases. It was launched in 2002 and has since helped slash the number of people dying from AIDS, TB and malaria.
Inkatha Freedom Party (IFP) leader iNkosi Mangosuthu Buthelezi says it is deeply worrying that South Africa remains one of the most dangerous countries for woman.
The United Nations AIDS agency UNAIDS warned in July that complacency was starting to stall the fight against the global epidemic, with the pace of progress not matching what is needed. Some 37 million people worldwide are infected with HIV.
Civil sector organisation Section 27 says political instability affects the provision of health services in South Africa.
It kills millions of people and is carried by a quarter of humans, yet there has been just a handful of new drugs in decades and the only vaccine is a century old.