The two clubs will meet at the King Zwelithini Stadium in Umlazi.
USuthu will be seeking to bring an end to the 12-years of nightmare against Amakhosi.
Chiefs have enjoyed some good times playing against AmaZulu five seasons ago – Chiefs trounced the KwaZulu-Natal based team by 6-0.
The last time AmaZulu beat Chiefs was in 2007, when they won by 2-1. Van Heerden says his side is in top form.
“It is always an interesting match between the teams, Chiefs and AmaZulu. From our form this year at home, it is going to be very tough for them to come away with something from here.”
Meanwhile, Kaizer Chiefs will visit AmaZulu on the back of a defeat against Zambian side Zesco United in the Confederation Cup.
Despite their loss to United, Amakhosi have done well in the domestic league since the arrival of Ernest Middendorp.
Van Heerden says it is difficult to play against a wounded lion.